Synthesis, Characterization, Thermal and Antimicrobial Properties of 1-((5-Nitrobenzothiazol-2-ylimino)methyl)-2-naphthol and its Complexes with Co(II), Ni(II), Cu(II) and Zn(II)

Abstract

1-((5-nitrobenzothiazol-2-ylimino)methyl)-2-naphthol (LH), has been synthesized from 2-hydroxynahthaldehyde and 2-aminobenzothiazole in ethanol. Metal complexes prepared from acetate salts of Co(II), Ni(II), Cu(II) and Zn(II) in 1:1 methanol/dioxan mixture. Characterization of the ligand and its complexes were made by microanalyses, FT-IR, 13C, 1H NMR, and UV-Visible spectroscopy, magnetic susceptibility, thermogravimetric analysis. Antimicrobial properties of the synthesized compounds were tested against the Gram-positive Bacillus subtilis, Staphylococcus aureus, the Gram-negative Escherichia coli, Salmonella typhimurium and the yeast Candida globrata and Candida tropicalis using a standard broth dilution technique, and compared to ampicillin and fluconazol as standard drugs. All the complexes and the ligand showed some degree of cytotoxic activity.