Pharmacological evaluation of a phenyl boronic acid derivative having antibacterial activity against S. aureus : Synthesis, biological activity, and ADME Studies
DOI:
https://doi.org/10.5281/zenodo.17897569Abstract
Boron-containing compounds have attracted considerable attention due to their unique chemical reactivity, biological versatility, and low toxicity. In this study, a phenylboronic acid (PBA) derivative (3-((3,5-ditert-butyl-2-hydroxybenzylidene)amino)phenyl)boronic, 3,5-Tb-Bmin) was synthesized and characterized using elemental analysis and spectroscopic techniques. The in vitro antibacterial activity of the compound 3,5-Tb-Bmin against Staphylococcus aureus was determined by the broth microdilution method (BMD) . The results revealed that the synthesized boron derivative exhibited significant inhibitory activity, suggesting its potential as a promising antibacterial agent. Furthermore, ADME (Absorption, Distribution, Metabolism, and Excretion) analysis was performed to assess the pharmacokinetic behavior and drug-likeness of the compound. The results indicated favorable oral bioavailability, acceptable lipophilicity, and compliance with Lipinski’s rule of five. These findings demonstrate that the synthesized boronic acid derivative could serve as a potential lead compound for the development of novel boron-based antibacterial drugs.
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