An Investigatıon of the Effects of 2-Aminoimidazoline Derivative on the Levels of Antioxidant Vitamıns (A, E, and C) and MDA of Rats
DOI:
https://doi.org/10.5281/zenodo.15252058Keywords:
2-Aminoimidazoline derivative, Vitamin A, Vitamin E, Vitamin C and MDA, RatAbstract
This study was carried out to determine the amounts of malondialdehyde (MDA) and vitamins A, E, and C, which are indicators of lipid peroxides, in the blood serum, liver, and kidney tissues of rats given N-(5-phenyl[1,3,4]-thidiazol-2-yl)-N-(4,5-dihydro-1H-imidazol-2yl) amine using high performance liquid chromatography (HPLC).
2-Aminoimidazoline derivative was injected into the 9 rats of 25 mg kg-1 (dissolved in 250 µL of %75 ethanol). For the control group, only 250 µL of %75 ethanol was injected into the other 7 rats for 16 days (every other day). Afterward, all rats failed using ether and blood serum, and liver and kidney tissues were taken.
It was found that the level of C vitamin in rats under the skin of which we injected thiadiazolimidazoline was lower than that in the control group (p<0.005). The same results were observed for A and E vitamins in serum and for A, E, and C in liver and kidney tissues (p<0.05).
It was observed that MDA levels of the liver and serum of rats in which the 2-aminoimidazoline derivative was injected were higher than in the control groups (p0.005). Moreover, this level was higher in the rats under the skin, for which we injected 2-amino imidazoline derivative, than in the control groups for kidney tissues (p<0.05). These observations show that the production of free radicals was increased by the 2-amino imidazoline derivative, producing stress in rats. Because of the same reason, the antioxidant level was decreased.
In conclusion, using antioxidant vitamins with drugs containing any 2-amino imidazoline derivative is beneficial.
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